When Hoodia was discovered the very first animal trials to test it was with Rats. The rats that were fed with Hoodia stopped eating completely. Rats are well know as animals that will eat anything and everything. Can you believe that an animal who loves to eat anything simply switched off its desire to eat, even when foods that rats love were placed in front of them. When the first clinical human trial was conducted with Hoodia, several morbidly obese people were placed in a unit which was a closed off area were all that they could do was to read, watch television, interact with each other, and of course eat. Half the people were given Hoodia Gordonii to take, and half were given a placebo. After fifteen days, the group that had been taking Hoodia Gordonii had reduced their calorie intake by 1000 calories a day - despite taking no exercise and not being on a diet This is due to the active ingredient in Hoodia Gordonii, the molecule known as P57, as it imitates the effects that glucose has on your brain, signaling that you are full. Your brain has what is called a Hypothalamus. This part of your brain controls your appetite. When you eat, the glucose levels in your body rise. As these levels go up, the hypothalamus sends off a signal to your cells to stop eating. This is when you start to feel full. Hoodia Gordonii's molecule, P57, tells your brain the same exact thing, even if you haven't eaten a bite. By mimicking the effects of glucose on your brain, the hypothalamus starts to send messages to your cells which in turn, make you feel full Hoodia is grown in the Kalahari Desert region of South Africa, Hoodia Gordonii is an all natural appetite suppressant, derived from a cactus like plant with prickly spikes. Scientists have been researching the Hoodia plant for almost a decade, and have found it to be completely free of harmful side effects.