Lyrica, also known as pregabalin derived from a prohibited neurotransmitter, gamma-aminobutyric acid (GABA). Lyrica has been standardised by the FDA for diabetic nerve ache and postherapetic nerve ache. Lyrica connects to calcium path in the central nervous system. Its outcome is realised due to its ability to trim down the calcium dependent release of several neurotransmitters. Researchers at the University of Michigan assessed the efficiency and security of pregabalin for the treatment of fibromyalgia (FM) in an eight-week, placebo-controlled, phase II test. The patients were given with pregabalin doses of 150mg, 300mg, or 450mg per day or with a placebo. The total dosage were fragmented into three doses a day and consumed for eight weeks. After a one-week baseline-watching period, the primary measurement of efficiency was the pain level at the end of the eight weeks. This information was taken from daily ache diaries. Patients treated with lyrica had statistically momentous improvement in their average pain score contrasted with the placebo. The patients who are treated with lyrica, 28.9 percent had a statistically noteworthy (greater than 50 percent) drop in pain from baseline matched up to 13.2 percent of patients treated with the placebo. Forty-eight percent of patients in the lyrica of the 450mg per day group had at least a 30 percent statistically momentous fall in pain from baseline compared to 27 percent on the placebo. The significant progress in pain happened as early as week one. There were major improvements in practical ways such as sleep, fatigue, and activity of life. The most common treatment events were drowsiness and faintness and were considered to be dose related. Discontinuous rates owed to side effects were less than 10 percent. Fibromyalgia experts have used Lyrica in practice and more medical information regarding its effect on Fibromyalgia is yet to come out.