Women, regardless of nationality or socioeconomic status, have a higher chance to have depression than men. The reasons for such higher chance appear to be a combination of biological and cultural factors. Women's Hormonal Variation and Life Phase Extreme hormonal changes can trigger the reaction of emotional swings for all women. There are studies that show how the hormones can contribute in depression but the reason is not yet totally clear. Female hormones undoubtedly play a big role in “premenstrual dysphoria”, postpartum depression, and the SAD moment. These forms of depression draw back or stop after the menopausal stage. In early puberty a girl who reaches the age of 11 years old or younger are more prone to experience depression during adolescence than those girls that are more matured. By the time of pre-menopausal, women between the ages of 20 and 45 are most at risk to get depression. Based on the record of the study, 34% of this age group are complaining of having symptoms of major depression. Depression usually occurs around menopausal stage, it is the stage when the women's hormonal secretion changes. Usually symptoms like lack of sleep, mood swing, hypertension, and loss of appetite are experienced. Once the women pass into the postmenopausal stage, some of the studies show that the average depression scores are nearly as low as those women that are under premenopausal stage. As a matter of fact, there are women cases that shows that after they had experienced menopause, they had also suffered from depression. One of the particular cause in that case is the seasonal changes. There are other studies in United States that have reported that even grandmothers who shows care for their grandchildren and family, not considering the situation in which they work outside or at home, have a high risk for depression, other factors may be involved.