You want a wrinkle free skin? Check out the following options that you have to keep your skin wrinkle free. Retinols Retinol is the principle Vitamin A, and fills all the roles that Vitamin A plays metabolically. Vitamin A used in the treatment of the skin conditions, cystic acne and psoriasis. Many Vitamin A effects are hormone-like, influencing the growth and differential of cells. Vitamin A can also be considered a biological response modifier. Retinol works by speeding up the cellular turnover rate, which allows the healthier cells to work their way up to the surface faster and by decreasing the activity of the destructive enzyme collagens. Collagen Collagen is the main protein of connective tissue in animals and the most abundant protein in mammals, making up about 1/4 of the total. It is one of the long, fibrous structural proteins whose functions are quite different from those of globular proteins such as enzymes. Collagen is an important source of moisture for the skin, and is particularly effective if it can develop its effect from directly within the body. Hormones A hormone, such as insulin or estrogen, is a substance released by an organ or tissue that controls the activity of organs or cells in another part of the body. Of all hormones that decline with age, estrogens have the most dramatic effect on the skin. Estriol is the "weakest" of the estrogens. As a topical treatment for the skin, estriol has been used to manage the effects of aging and menopause. This includes not only the anti-aging benefits like decreasing facial wrinkles and smoothing skin, but also an assortment of benefits that stem from helping to maintain healthy skin in the vagina, cervix, vulva, and urethra. Scientific studies validate that diminishing hormone levels play a significant factor in aging of facial skin and that estriol represents a new and promising therapeutic approach. Remember that if you are using an Estrogen Patch, it may have side effects like skin redness and irritation at the site of the patch One way to help skin retain the estrogen it needs for collagen production is by topically applying low levels of natural bio-identical estrogens on the face. For further details visit Best Anti Wrinkle Cream