Laser appears to be a good therapy for acne without side effects. Lasers and light-based systems have become one of the more common modalities to treat a wide variety of skin disorders, including acne vulgaris, during the past ten years. A lot of patients do not respond adequately or develop side effects with the various oral and topical treatments available for the treatment of acne. Hence, the growing demand by patients who suffered from acne for a faster, safer, and side-effect-free novel therapy. The Dermatology and Lasers Clinic from Tel Aviv Msq, Caesarea, Israel, studied this concerning situation in order to address the role of light therapy in the armamentarium of treatments for acne vulgaris, to discuss photobiology aspects and biomedical optics, to review current technologies of laser/light-based devices, to review the clinical experience and results, and to outline clinical guidelines and treatment considerations, as they reported. After a series of clinical trials, results show that 85 per cent of the patients show an important quantitative reduction in at least 50 per cent of their lesions after four biweekly treatments. Approximately 20 per cent of cases demonstrate that acne eradication may reach 90 per cent. Three months after the last treatment, clearance is approximately 70 per cent to 80 per cent. Meanwhile, the non-respondent rate is 15 per cent to 20 per cent. According to researchers, laser and light-based therapies are a safe and effective modality for the treatment of mild to moderate inflammatory acne vulgaris. After comparing to the effects of oral antibiotics, amelioration of acne by light therapy offers faster resolution and fewer side effects and leads to patient satisfaction.